The R622 is a Regional Route in KwaZulu-Natal, South Africa that connects Mooi River with Greytown.

[1] Its western terminus is the R103 at Mooi River.

It passes under the N3 and exits the town to the east.

It runs east to end at Greytown at an intersection with the R74.

This South African road or road transport-related article is a stub.