The R62 runs through the Little Karoo and the Langkloof, passing through Montagu, Ladismith, Calitzdorp, Oudtshoorn, and Joubertina.

[1] The R62 begins in the Breede River Valley at an intersection with the R60, 5 km (3.1 mi) east of Ashton.

It then follows the northern foothills of the Langberg mountains as far as Barrydale, before heading in a north-easterly direction to Ladismith.

The route then heads east to follow the Swartberg Mountains, crossing the Gamka River through the Huisrivier Pass and passing through Calitzdorp before reaching the Little Karoo's largest town, Oudtshoorn.

[1] At Oudtshoorn, the R62 heads south and is concurrent with the N12 in the direction of George for 33 km (21 mi) until reaching the N9/N12 intersection at the northern edge of the Outeniqua Mountains.