2OVJ, 3W6R, 3WPQ, 3WPS, 4B6D, 5C2J, 5C2K2912726934ENSG00000161800ENSMUSG00000023015Q9H0H5Q9WVM1NM_001320001NM_001320002NM_001320003NM_001320004NM_001320005NM_001320006NM_001320007NM_001253808NM_001253809NM_012025NP_001306931NP_001306932NP_001306933NP_001306934NP_001306935NP_001306936NP_037409NP_001240737NP_001240738NP_036155Rac GTPase-activating protein 1 is an enzyme that in humans is encoded by the RACGAP1 gene.

GTPase-activating proteins (GAPs) bind activated forms of Rho GTPases and stimulate GTP hydrolysis.

Through this catalytic function, Rho GAPs negatively regulate Rho-mediated signals.

GAPs may also serve as effector molecules and play a role in signaling downstream of Rho and other Ras-like GTPases.

RACGAP1 also interacts with PRC1 to stabilize and maintain the central spindle as anaphase proceeds.