[8] The BCDX2 complex appears to act by facilitating the assembly or stability of the RAD51 nucleoprotein filament.

[8] The CX3 complex was shown to associate with Holliday junction resolvase activity, probably in a role of stabilizing gene conversion tracts.

[8] The RAD51C gene of rice has an essential role in meiosis in both male and female gametocytes.

Overexpression of the four genes during amplification has been observed and suggests a possible role in tumor progression.

Alternative splicing has been observed for this gene and two variants encoding different isoforms have been identified.

The authors concluded that variant 1 mRNA was associated with the malignant phenotype of colorectal cancers[20] In the case of gastric cancer, reduced expression of RAD51C was found in about 40% to 50% of tumors, and almost all tumors with reduced RAD51C expression had methylation of the RAD51C promoter.

[25] Increased expression of EZH2, leading to repression of RAD51 paralogs and consequent reduced homologous recombinational repair, was proposed as a cause of breast cancer.