In April 2022, the centre retired its two BAE Systems Hawk T1 which were based at MOD Boscombe Down in Wiltshire.

Flying fast-jet aircraft puts the cardiovascular physiology of the human body under extreme physical stress.

Other dangers include rapid uncontrolled decompression from failure of cabin pressurisation, and the centre has four hypobaric chambers.

Airlines that do not have their own aviation medicine research establishments (e.g. British Airways) have contracted out work to the RAF's Centre.

[citation needed] King's College London School of Medicine and Dentistry at Guy's Hospital has run a MSc programme in aviation medicine, which involves the RAF's Centre, specifically the practical experience of G-forces, decompression, whole-body vibration, and vestibular (balance sensory system) and visual disorientation.