1Z5S, 2GRN, 2GRO, 2GRP, 2GRQ, 2GRR, 2IY0, 3UIN, 3UIO, 3UIP, 5D2M, 2IO2, 2IO3590519387ENSG00000100401ENSMUSG00000022391P46060P46061NM_001278651NM_002883NM_001317930NM_001146174NM_011241NM_001358622NP_001265580NP_001304859NP_002874NP_001139646NP_035371NP_001345551Ran GTPase-activating protein 1 is an enzyme that in humans is encoded by the RANGAP1 gene.

[5][6] RanGAP1, is a homodimeric 65-kD polypeptide that specifically induces the GTPase activity of RAN, but not of RAS by over 1,000-fold.

RanGAP1 is the immediate antagonist of RCC1, a regulator molecule that keeps RAN in the active, GTP-bound state.

The sequence is unrelated to that of GTPase activators for other RAS-related proteins, but is 88% identical to Rangap1 (Fug1), the murine homolog of yeast Rna1p.

Small ubiquitin-related modifier needs to be associated with it before it can be localized at the nuclear pore.