2IJE592319417ENSG00000058335ENSMUSG00000032356Q13972P27671NM_001145648NM_002891NM_153815NM_001039655NM_011245NM_001357743NM_001357744NP_001139120NP_002882NP_722522NP_001034744NP_035375NP_001344672NP_001344673Ras protein-specific guanine nucleotide-releasing factor 1 is a protein in humans that is encoded by the RASGRF1 gene.

[5] The protein encoded by this gene is a guanine nucleotide exchange factor (GEF) similar to the Saccharomyces cerevisiae CDC25 gene product.

The studies of the similar gene in mice suggested that the Ras-GEF activity of this protein in the brain can be activated by Ca2+ influx, muscarinic receptors, and G protein beta-gamma subunit.

Mouse studies also indicated that the Ras-GEF signaling pathway mediated by this protein may be important for long-term memory.

Alternatively spliced transcript variants encoding distinct isoforms have been reported.