[4][5] The protein encoded by this gene is a brain-enriched nucleotide exchange factor that contains an N-terminal GEF domain, 2 tandem repeats of EF-hand calcium-binding motifs, and a C-terminal diacylglycerol/phorbol ester-binding domain.

This protein can activate small GTPases, including RAS and RAP1/RAS3.

The nucleotide exchange activity of this protein can be stimulated by calcium and diacylglycerol.

Two alternatively spliced transcript variants of this gene, encoding distinct isoforms, have been reported.

This article on a gene on human chromosome 11 is a stub.