25780240168ENSG00000152689ENSMUSG00000071042Q8IV61Q6NZH9NM_001349977NM_001349978NM_001349979NM_001349980NM_001349981NM_001166493NM_207246NM_001360103NP_001336906NP_001336907NP_001336908NP_001336909NP_001336910NP_001159965NP_997129NP_001347032Ras guanyl-releasing protein 3 is a protein that in humans is encoded by the RASGRP3 gene.

[5][6][7] Members of the RAS (see HRAS; MIM 190020) subfamily of GTPases function in signal transduction as GTP/GDP-regulated switches that cycle between inactive GDP- and active GTP-bound states.

Guanine nucleotide exchange factors (GEFs), such as RASGRP3, serve as RAS activators by promoting acquisition of GTP to maintain the active GTP-bound state and are the key link between cell surface receptors and RAS activation (Rebhun et al., 2000).

[7] RASGRP3 has been shown to interact with PRKCD.

[8] This article on a gene on human chromosome 2 is a stub.