RK Tutunski Kombinat (HC Tutunski Kombinat) (Macedonian: РК Тутунски Kомбинат Бренд) was a team handball club from Prilep, Republic of Macedonia.

RK Prilep have played his first season in the strongest Macedonian handball league.

In 2014–15 season RK Prilep was 2nd on the table which gone the team in the play-off.

In the play-off, in the league have joined Macedonia two biggest clubs: Vardar and Metalurg.

The draw for the EHF Cup decided RK Prilep to play against HC Pfadi Winthentur.