54476108086ENSG00000011275ENSMUSG00000045078Q9NWF9P58283NM_019011NM_207111NM_207116NM_001377156NM_080561NM_207110NM_001359851NP_996994NP_996999NP_001364085NP_542128NP_996993NP_001346780E3 ubiquitin-protein ligase RNF216 is an enzyme that in humans is encoded by the RNF216 gene.

Zinc finger domains of the encoded protein are required for its interaction with RIP and for inhibition of TNF- and IL1-induced NF-kappa B activation pathways.

The encoded protein may also function as an E3 ubiquitin-protein ligase which accepts ubiquitin from E2 ubiquitin-conjugating enzymes and transfers it to substrates.

Several alternatively spliced transcript variants have been described for this locus but the full-length natures of only some are known.

[7] This article on a gene on human chromosome 7 is a stub.