In 2000, she made her debut as Pamina (The Magic Flute) at the Stadttheater Bern under the direction of Miguel Gomez-Martinez and at the Zürich Opera House with Franz Welser-Möst.
In 2007, she made her debut at the Deutsche Oper Berlin as Pamina, followed by her first Amor in Orfeo ed Euridice conducted by Leopold Hager in 2008 and Clémence in Kaija Saariaho's L'amour de loin) in Antwerp and Ghent in 2009.
[1][2] In 2012, she sang Hélène d'Egmont in the world premiere of Gaetano Donizetti's Le duc d'Albe at the Vlaamse Opera in Antwerp and Ghent.
[3][4] As a concert singer, Harnisch sang Luigi Nono's Prometeo-Suite, Tippetts A Child of Our Time, Schumanns Szenen aus Goethes Faust, Mendelssohn's Elijah and A Midsummer Night's Dream, Debussy's Le Martyre de Saint Sébastien, Haydn's the Creation and the Caecilien-Messe, Händel's Messiah, Bach's St John Passion, Mahler's Symphony No.
[5][6] With Lieder recitals - together with Irwin Gage, Maurizio Pollini, Cedric Pescia and Jan Philip Schulze - she has performed in Zurich, Geneva, Bochum, Berlin, Bern, Florence, Perugia, Rome and at the Lucerne Festival.