In 2011, Chris Ying of Lucky Peach, who Khong had met while interning at McSweeney's, asked her to be the managing editor of the magazine.

[9] Khong cofounded The Ruby in 2018, a female oriented co-working space based in Mission District, San Francisco.

[11] Her first novel, Goodbye, Vitamin, received Best Book of the Year honors from NPR,[12] O, The Oprah Magazine,[13] the San Francisco Chronicle,[14] and Vogue.

[19] FilmNation Entertainment announced on February 5, 2021 that they and Ali Wong are producing an adaptation of Khong's short story, The Freshening, with director Cathy Yan set to write and direct.

[20] She has written book reviews for the New York Times, including of novels by Maria Kuznetsova[21] and Sarah Elaine Smith.