Márquez began his professional boxing career with an eighth-round knockout loss to former WBC Bantamweight champion Victor Rabanales.
[2] He gained recognition by defeating two division world champion and future hall of fame member Mark Johnson (40-1-0) by a split decision.
His notable title defenses were two victories over former light flyweight champion Mauricio Pastrana, a decision win over Ricardo Vargas and two knockout victories over former as well as future IBO Bantamweight champion Silence Mabuza, whom he defeated for the second time on August 5, 2006 in his final defense.
[2] Márquez moved up a weight division to challenge and defeat WBC and lineal super bantamweight champion Israel Vázquez in seven rounds.
However, in a rematch in July 2007, Márquez lost his title after being defeated by Vázquez in the sixth round when the referee stopped the fight.
[4] After three epic battles, Vázquez and Márquez fought for a fourth time on May 22, 2010 at the Staples Center in Los Angeles, California.
[8] It was later revealed that Márquez had suffered a hairline fracture in his right shoulder blade during the fight and would require 6 months to recover from the injury.
[9] On 16 July 2011, Márquez made his comeback in Cancún on the same card as his brother, Juan Manuel, against Eduardo Becerril.
Márquez fought against WBC Super Bantamweight champion Toshiaki Nishioka on 1 October at the MGM Grand Garden Arena in Las Vegas.