Rafael Francisco Santana de la Cruz (born January 31, 1958) is a Dominican former Major League Baseball shortstop who won a World Series ring with the 1986 New York Mets.

Signed by the New York Yankees as an amateur free agent in 1976, Santana spent several years in their farm system before being traded to the St. Louis Cardinals on February 16, 1981 for a player to be named later.

Oquendo was traded with Mark J. Davis to the St. Louis Cardinals for Ángel Salazar and John Young during the offseason, making Santana the regular Mets shortstop for 1985.

Santana started all 13 games for the Mets during the 1986 post-season, and established an NLCS record for most putouts (13), assists (18) and chances accepted (31) by a shortstop in a six-game series against the Houston Astros.

After the 1987 campaign where he set career-highs in home runs (5) and RBIs (44) with the Mets, Santana was traded to the cross-town Yankees with Victor Garcia for Steve Frey, Phil Lombardi and Darren Reed.

In January 1990, Santana signed with the Cleveland Indians, where he played 7 games and was reunited with 1986 Mets teammates Keith Hernandez, Jesse Orosco, and Stan Jefferson.