Palladino started his senior career at Sporting Benevento, before joining the youth ranks of Juventus in 2002, where he achieved the Torneo di Viareggio in 2003 and 2004.

[2] On 3 July 2008, Palladino was signed by Genoa in co-ownership deal, priced €5million (for 50% rights), joined along with defender Domenico Criscito on loan.

[17] After having reached the semi-finals of the 2021–22 Campionato Primavera 2 (under-19) promotion play-offs, Monza renewed Palladino's contract for a further year in July 2022.

[18] On 13 September 2022, Palladino was promoted head coach of Monza's first team following the dismissal of Giovanni Stroppa,[16] with club CEO Adriano Galliani stating his appointment to be on a permanent basis.

[19] On his debut, Palladino guided Monza to their first ever top flight win, defeating Serie A powerhouse Juventus 1–0.

He was known in particular for his excellent technical ability and dribbling skills, as well as his pace and agility on the ball, which allowed him to beat opposing players and create space for himself to get into positions from which he can strike on goal.