Vasari thought the artist died at Florence in 1524, but he was certainly alive in 1527, when he was described as fit for military duty.

Raffaellino produced altarpieces, frescoes and small scale religious works for domestic interiors.

Four extant altarpieces are signed and dated: Other altarpieces include the Pietà of about 1497, originally in the Nasi chapel in Santo Spirito, Florence, and now at the Alte Pinakothek in Munich;[4] the Resurrection of about 1498 for the church of the Benedictine monastery of Monte Oliveto, Florence, now in that city's Galleria dell'Accademia; and the Madonna and Child with Saints John the Evangelist, Lawrence, Stephen and Bernard for the Segni chapel in Santo Spirito, which remains in its original location, in its original frame, and is inscribed with the date of 1505.

In 1503 he frescoed the Miracle of the Loaves in the refectory of the Florentine convent of the Cestello (now called Santa Maria Maddalena dei Pazzi), now detached and displayed alongside its sinopia (underdrawing) in the church of Sant'Antonino a Bellariva in the outskirts of Florence.

Raffaellino's large Coronation of the Virgin, painted in 1511 for the high altar of San Salvi, Florence, where it was described by Vasari, is now at the Musée du Petit Palais, Avignon.