The Ragusano is a breed of donkey from the Mediterranean island of Sicily.

[2] It is associated particularly with the comuni of Modica, Ragusa, Santa Croce Camerina and Scicli, all in the Province of Ragusa in southern Sicily.

[3] It is one of the eight autochthonous donkey breeds of limited distribution recognised by the Ministero delle Politiche Agricole Alimentari e Forestali, the Italian ministry of agriculture and forestry.

[1] The milk of the Ragusano donkey has demonstrated remarkable antiviral properties and some scientists believe it could be useful in preventing viral human gastrointestinal infections.

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