Raja Muhammad Afzal Khan (Urdu: راجہ محمد افضل خان; 1 March 1936 - 11 April 2020) was a Pakistani politician.He belongs to a Rajput family of the Janjua clan.

In 1983, Raja Afzal started his political career by winning Jhelum Municipal Committee chairman election and later on from 1985 to 1999, he remained MNA and senator, mostly from the PML-N.

In 2002, he could not contest the poll due to graduation bar and fielded his two sons Raja Asad and Raja Safdar as PML-N nominees on National Assembly seats of Jhelum and only Asad won but in 2008 his both sons won NA seats.

[3][4] Although the senior politician had enjoyed a long association with the Sharif family and PML-N, they developed differences in late 2012.

[6][7] Raja Afzal contested as a PPP nominee on two seats in the 2013 election but lost the poll.