[6] Following a near-fatal bout with throat cancer,[2] Amyx founded American Heritage Manuscripts and Collectibles.

[4] Amyx claims he started collecting at age seven, when he "opened" a museum consisting of some coins, stamps, butterflies and a dead bat.

Amyx was inspired to gather mementos from former White House employees into a collection, and placed numerous advertisements in The Washington Post.

[4] Amyx has since worked with some 100 people who have held long-term household positions for First Families since the days of Herbert Hoover, and some whose parents and/or grandparents served in the White House as far back as the 19th century.

One piece from the collection was traded to Robert L. McNeil and is featured in the book American Presidential China.

Amyx possesses three official Super Bowl rings presented to Washington Redskins players in 1982, 1987 and 1991.

[11] His collection includes over 50 Olympic medals in gold, silver, and bronze dating back to 1896.

Amyx has acquired, authenticated, and appraised historical items for collectors and for entities such as the Smithsonian Institution.