During his junior year he decided to pursue surgery and was accepted into the Yale Training Program.

[5] He joined the faculty at Rutgers (later Robert Wood Johnson Medical School) as an Assistant Professor of Surgery in 1975.

In 1978 in collaboration with Richard Harvey Ph D, professor of biochemistry, Greco developed the hypothesis that bio-materials could be rendered infection resistant by bonding antibiotics to their surfaces.

[11] First he worked with a small number of faculty and residents to create a well being program entitled Balance in Life,[12] which became a model for others.

[13] Greco received the 2011 John Gienapp Award for lifetime contributions to GME, the highest honor given by the ACGME.