Danforth formed a partnership with George Robinson; William Andrews entered the business of feeding farm animals by founding the Robinson-Danforth Commission Company.

In 1998, Ralston Purina spun off its international animal feed business as Agribrands, which was acquired by Cargill in 2001.

In 1993, Ralston Purina also bought Breckenridge ski area for an undisclosed amount, from Victoria U.S.A. Inc, a Japanese sporting goods retailer.

[8] In 1977, Ralston Purina acquired Missouri Arena Corporation and the St. Louis Blues National Hockey League franchise.

During the company's ownership of the team, they changed the name of the St. Louis Arena to the Checkerdome, reflecting the Ralston Purina logo.

Ralston Purina purchased Continental Baking Company, makers of Wonder bread and Hostess cakes, from ITT in 1984.

Ralston spun off Continental Baking Company, subsequently bought by Irving, Texas–based Interstate Brands Corporation (IBC).

They did well, but Ralston Purina decided not to enter the pizza franchise business and closed all pilots by late 1987.

Danforth used the design as the visualization of a concept put forth in his book I Dare You, in which he proposed that four key components in life ("Physical", "Mental", "Social", and "Religious") need to be in balance, and one area was not to develop at the expense of the others.