Ramfis was born in 1929, his mother was María de los Angeles Martínez Alba, nicknamed La Españolita "the little Spaniard" as her parents were from Spain.

His unruly behavior, including gang rapes of young women and frivolously ordering murders, forced his father to send him to a sanatorium in Belgium.

Trujillo apparently suffered from psychological problems, possibly the result of the pressure that his father constantly placed on him, as he intended to remake his son into an image of himself.

She was an American of Hungarian immigrant parents, who had a short but relatively successful film career in Hollywood, most notably in The Left Handed Gun, opposite Paul Newman.

Ramfis quickly returned to the country and, with the help of Johnny Abbes García, the ruthless intelligence chief, brutally repressed any elements believed to be connected with his father's death, murdering many of the suspects himself.

However, these concessions were rejected as insufficient by a people whose only memories had been the Trujillo era, rather than the decades of poverty and instability which had preceded it (bankruptcy in 1902–1905, civil war in 1911—12 & 1914, U.S. occupation in 1916–1924).

[5] Both internal and external pressures forced him into exile late in 1961, when he fled back to France, along with all of the surviving Trujillos, aboard the famed yacht Angelita (still sailing today as the cruise ship Sea Cloud), with his father's casket, which was allegedly lined with $4 million (equivalent to $31 million in 2023) in cash, jewels and important papers.

He died on 27 December 1969 in a Spanish hospital due to complications from pneumonia after being severely injured in a car crash ten days[6] earlier in the outskirts of Madrid.