[citation needed] Khouri is former director of the Issam Fares Institute for Public Policy and International Affairs (IFI) at the American University of Beirut.

Khouri also serves as editor at large of the Beirut-based Daily Star newspaper, published throughout the Middle East with the International Herald Tribune.

Khouri also serves on the board of the EastWest Institute, the Center for Contemporary Arab studies at Georgetown University and the National Museum of Jordan.

He also wrote for many years from Amman, Jordan for international publications, including the Financial Times, the Boston Globe and the Washington Post.

For 18 years he was general manager of Al Kutba, publishers, in Amman, and has served as a consultant to the Jordanian tourism ministry on Biblical archaeological sites.

Writing for a Lebanese newspaper, the Daily Star, he stated that "We end up with a situation in which it becomes easy for Arabs to blame Israel and the Western powers for the problems of our region."