Joaquin Ramon Cesareo Manuel Santamarina (February 25, 1827 – August 23, 1904) was an Argentine businessman of Spanish origin.

While being in A Coruña, Jose Santamarina due to his large economic problems committed suicide in front of Ramon.

In 1896 Christian IX of Denmark awarded Santamarina the Knight Order of the Dannebrog, because of his efforts for the settlement of Danish emigrants in Buenos Aires.

The firm is devoted to various branches of economy, among which are rural and urban government establishments, industrial, banking businesses, and fruit transport.

All these establishments are scattered throughout the provinces of Buenos Aires, Santa Fe and Santiago del Estero.

The college of San Jose in Tandil was built to honor Ramon Santamarina, while the city's hospital was named after him on March 10, 1912.