[2] Ramona offers a rigorous and personalized college-prep program with a wide array of Advanced Placement, Honors, Arts, STEM (Science, Technology, Engineering, and Math), and elective courses, including the AP Capstone Program with its emphasis on college-level research, writing, and presentation skills and AP Computer Science Principles.

The Sisters of the Holy Names of Jesus and Mary came from Oakland, California at the request of several prominent San Gabriel Valley families interested in the Catholic education of their daughters.

Approximately 4 acres (1.6 ha) of the southwestern section of Ramona's property were sold In 1979 in order to help fund further implementation of the Master Plan.

[citation needed] A building to house administrative offices, kitchen and dining facilities, and a chapel was dedicated on November 12, 1989, the beginning of Ramona's second century.

Ramona athletes complete on 13 teams in seven sports: basketball, cross country, soccer, softball, swimming, track & field, and volleyball, in the Horizon League under the California Interscholastic Federation.