Ramos Mejía was the son of a merchant from Seville, and had returned from a nine-year stay in the Upper Peru, where his business interests had met with success.

They, in turn, sold the first lots to the Buenos Aires Western Railway, which opened the station at the site on September 25, 1858, along the nation's first rail line.

[3] Buoyed by the subsequent wave of immigration in Argentina, Ramos Mejía grew rapidly and in 1904, the cobblestone Avenida Rivadavia reached the town from Buenos Aires.

The original station was replaced in 1907 by a larger structure designed by Dutch architect John Doyer; one of the most recognizable examples of Victorian architecture in Argentina, the building itself was converted to a museum in 2008.

[2] The city is the birthplace of, among other well-known personalities in Argentina, comedian Antonio Gasalla, cyclist and olympic gold medalist Walter Pérez, former Vice President Carlos Ruckauf, Governor Daniel Scioli, screenwriter Damián Szifrón, and songwriter María Elena Walsh.