[1] He plays keyboards, saxophones, flute, guitar, mandolin, and harmonica, and his songwriting is influenced by blues, folk, and gospel music.

Born in Jesup, Georgia, United States, Bramblett studied religion and psychology at the University of North Carolina, with the objective of entering the seminary.

However, finding inspiration in the music of James Taylor, Carole King, and Bob Dylan, he abandoned his theological studies and pursued songwriting, soon moving to Athens, Georgia.

[1][2] Bramblett, along with Chuck Leavell, has been credited with giving Sea Level, described as "a jazz-influenced spinoff from the Allman Brothers Band," a new, unique direction.

The title track was inspired by the story of Howlin' Wolf trying to reunite with his estranged mother, who had abandoned him for "playing the devil's music.