[4][5][6][7] The Saint was founded by Adam Jon Weisberg along with business partner Scott Stamper, and opened its doors on November 18, 1994.

The Saint was an early site of the annual Asbury Park Music Awards ceremony founded by Stamper in collaboration with Pete Mantas.

When the event's attendance exceeded The Saint's capacity, the ceremony was rotated among larger venues, including The Fastlane, The Tradewinds, and The Stone Pony.

On November 18, 2022, the owners of The Saint announced that they had lost their lease and liquor license, citing issues stemming from the COVID-19 pandemic.

Notable acts who have performed there include The Airborne Toxic Event, Nicole Atkins, Ben Folds Five, Bif Naked, Tracy Bonham, Buckethead, Cake, Cannibal Corpse, Ryan Cassata, Jen Chapin, Citizen Cope, Cowboy Mouth, Creed, The Dandy Warhols, Kimya Dawson, Deftones, Joe DeRosa, Dub Trio, The Duke Spirit, Everlast, Finger Eleven, Five for Fighting, The Ghost of a Saber Tooth Tiger, Green Jellÿ, Guster, John S. Hall, Robert Hazard, HelenaMaria, Hoobastank, Incubus, Jewel, Freedy Johnston, Joydrop, Kings of Leon, LP, The Lemonheads, Tony Levin, Toby Lightman, Lunachicks, Marcy Playground, Matthew Good Band, Anne McCue, Shannon McNally, Mindless Self Indulgence, Mod Fun, Modern English, Moe, Allie Moss, Moxy Früvous, Mucky Pup, Nada Surf, Leona Naess, Mieka Pauley, The Pierces, Rachel Platten, Queens of the Stone Age, Joey Ramone, Scars on 45, Maia Sharp, Kenny Wayne Shepherd, April Smith and the Great Picture Show, Bruce Springsteen, Stereophonics, The String Cheese Incident, Kasim Sulton, Tegan and Sara, The The, They Might Be Giants, The Trashcan Sinatras, Derek Trucks, Ween, Wussy, and Zebrahead.