She is the former director of market development and spokesperson for Facebook, and a sister of the company's co-founder and CEO Mark Zuckerberg.

As of May 2014, she is founder and CEO of Zuckerberg Media, editor-in-chief (EIC) of Dot Complicated, a digital lifestyle website,[3] and creator of Dot., an animated television show about a young girl (the eponymous Dot) who uses technology to enhance both her educational experiences and recreational activities.

[4] After graduating from Harvard University, Zuckerberg worked for two years in marketing for advertising firm Ogilvy & Mather.

Since starting Zuckerberg Media, Randi has produced shows and digital content for BeachMint, the Clinton Global Initiative, Cirque du Soleil, the United Nations, Condé Nast and Bravo.

[3] Zuckerberg has written three adult non-fiction books: In the cartoon adaptation of Dot., she voices the character "Ms. Randi", Dot's music teacher who organizes the children's choir at the community center.