De Ocampo started playing organized basketball at the Saint Francis of Assisi College System Doves together with his brother, Yancy.

In 2008, de Ocampo was again included in the RP Training Pool, his second stint, assembled by the PBA under Coach Yeng Guiao.

In the middle of the 2008–09 PBA Philippine Cup, he was traded to the Talk 'N Text Tropang Texters for veteran Don Allado.

In 2015, de Ocampo led the Texters to the 2015 PBA Commissioner's Cup championship, winning a seven-game series against Rain or Shine Elasto Painters.

De Ocampo also buried a crucial three point field goal late in the fourth quarter which secured Gilas a slot in the 2014 World Cup.