Jacques Raphaël Lépine (6 July 1840 – 17 November 1919) was a French physiologist who was a native of Lyon.
At Karl Ludwig's laboratory in Leipzig he performed important studies on the vasomotor nerves of the tongue.
In 1870 he obtained his doctorate in Paris with a dissertation titled "De l'hémiplégie pneumonique".
Raphaël Lépine is known for his investigations in experimental medicine, that included extensive research involving glycolysis and the pathophysiology of diabetes.
[1] He was the brother of Louis Lépine, Prefect of Police for the Seine from 1893 to 1897 and again from 1899 to 1913.