He was also an executive producer and writer on the Netflix/Adult Swim animated series Tuca & Bertie (2019–2022), created by BoJack Horseman production designer Lisa Hanawalt.

[3][4] His father, David Waksberg, helped Russian-speaking Jews emigrate to the United States and served as CEO of Jewish LearningWorks, a San Francisco-based religious education center, until his retirement in 2020.

"[2] He has implied that his family perceived comedy as a viable career path, stating in a Times of Israel interview,Humor was a big part of my childhood.

[1][7] Conover and Bob-Waksberg were founding members of the sketch comedy group Olde English.

[6]Hanawalt's art, specifically her animal-human hybrid characters, inspired him to create BoJack Horseman,[6] and she eventually became the show's production designer and producer.

As a member of the Olde English comedy troupe, he co-wrote and appeared in The Exquisite Corpse Project.

[12] In March 2018, it was announced that he was co-creating an animated series for Amazon with Kate Purdy, which would be called Undone.

The show revolves around Alma, a Mexican American woman who discovers a "new relationship with time" after a near-fatal car crash and uses this to learn more about the truth behind her father's death.

[15] In August 2024, Netflix announced Bob-Waksberg would create, write and executive-produced a new adult animated comedy series titled Long Story Short, which is set to debut in 2025.