He played college football at Florida State, and was selected by the Jacksonville Jaguars in the fifth round of the 2015 NFL draft.

Greene attended Westover Comprehensive High School from 2007 to 2009, where he played football and was a standout at wide receiver.

[4] After his sophomore year, Greene transferred to St. Thomas Aquinas High School in Fort Lauderdale, Florida.

In the 2010 Class 5A State title game against Tampa's Plant High School, he recorded six receptions for 148 yards and two touchdowns, including a title-clinching 74-yard pass in the fourth quarter.

[6] Greene enrolled at Florida State University in the fall of 2011 under head coach Jimbo Fisher.

[10][11][12] As a senior in 2014, Greene set the school record for career receptions and receiving yards, passing Ron Sellers in both categories.

[18] On September 13, 2015, Greene scored his first professional touchdown on a one-yard reception from Blake Bortles in the season opener against the Carolina Panthers.