In embryogenesis, Rathke's pouch is an evagination at the roof of the developing mouth in front of the buccopharyngeal membrane.

It begins as an ectodermal invagination at the roof of the stomodeum, which extends dorsally towards the developing brain.

These conditions can result in pituitary dysfunction and present with symptoms such as hormonal imbalances, growth retardation, and visual disturbances.

[5] Current research on Rathke's pouch focuses on understanding the molecular mechanisms governing its development and differentiation.

Advances in genetic and stem cell research hold promise for developing novel therapies for pituitary disorders resulting from Rathke's pouch malformations.