Thyrotropic cell

In the image displayed on the right, thyrotropes are the cells with the bluish-purple cytoplasm and the dark purple nucleus.

[3] Thyrotrophs can be identified via immunocytochemistry as early as the 12th week of fetal development, roughly at the same time that gonadotrophs can be detected.

[5] The direct pathway from the release of calcium ions to the expression of these genes in thyrotropic cells is unknown.

[1] Thyroid hormones can have a direct inhibitory effect on thyrotropic cells, though the exact mechanism is unknown.

The presence of high affinity binding sites for GLP-1 was recently discovered in the thyrotropic cells of rodents.

Understanding this pathway can help the formulation of treatments for type II diabetes mellitus, as there exists a strong association between metabolic diseases and thyroid dysfunction.

Diffuse goitre refers to the elongated enlargement of the thyroid gland that results from the increased expression of TSH.

[10] In histological staining, the thyrotropic cells appear more elongated and spindle shaped and are regularly accompanied by fibrosis.

Disruption of the α-subunit gene results in a lack of TSH secretion, hypertrophy and hyperplasia of thyrotrophs, and decreased quantities of somatotrophs and lactotrophs.

In individuals with primary hyperthyroidism, treatment via thyroid hormone therapy can reverse the hypertrophy and hyperplasia of the thyrotrophs.

Individuals with a rare form of dwarfism characterized by hypothyroidism lack thyrotropic cells altogether, as this syndrome results from a mutation in the Pit-1 gene.

[3] Excess iodine present in individuals with Graves’ Disease can induce thyrotoxicosis, which is the overexpression of thyroid hormone.

Thyroid storm results in substantial decreases in the amount of thyrotropic cells in the pituitary gland.