Born in Baku, Mamedov started playing chess at the age of seven.

In 2009, he tied for 1st-3rd with Yuriy Kuzubov and Dmitry Andreikin in the category 16 SPICE Cup tournament at Lubbock, Texas.

[3] In 2016, he won the men's blitz chess event of the IMSA Elite Mind Games in Huai'an, China.

[6] In April 2018, he participated in the fifth edition of Shamkir Chess, finishing ninth with a score of 4/9 (+0–1=8).

[10] Rauf Mamedov is married to Ukrainian international master Nataliya Buksa.