Born in New York City, Meddine is a Lebanese Druze who has lived in several countries due to her father's work in diplomatic missions.
In February 2008, Meddine joined the cast of the American soap opera The Young and the Restless in the contract role of Sabrina Costelana Newman.
Some of her other acting roles include Isabelle in the Lebanese box office hit Bosta (2006), and as Wanda in the short award-winning film Recycling Flo (2004).
In January 2012, Meddine appeared on the pilot episode of the FOX television series, Touch, starring Kiefer Sutherland.
In 2018, she started to host a program titled "Bayneh W Baynek", with Nadine Labaki as the first guest, in which she discussed women issues.