The highway is named for Raymond Wieczorek, a five-term mayor of Manchester.

The drive passes under the turnpike, then comes to an interchange with U.S. Route 3 (South River Road).

The drive then crosses the Pearl Harbor Memorial Bridge over a set of railroad tracks, the Merrimack River, and New Hampshire Route 3A (Brown Avenue), entering the city of Manchester at the midpoint of the river.

The drive then passes through a traffic-light controlled intersection with Roundstone Drive and Pettengill Road (opened December 21, 2015), then crosses the Sora-Currier USMC Memorial Bridge over a small valley.

Raymond Wieczorek Drive ends at a second roundabout, intersecting Airport Road and Galaxy Way.