In domestic football, the club has won a record 8 Segunda División titles and 1 Spanish Royal Federation Cup.

[2] In that season, the team also equalled its best run in the Copa del Rey by reaching the quarter-finals before losing on the away goals rule to Deportivo de La Coruña, despite a 4–3 win in the second leg at home.

[5] In 2014, the team finished fourth and was top seeded for the playoffs, losing 2–1 on aggregate to eventual winners Córdoba CF;[6] weeks later Murcia were relegated for non-compliance with Liga de Fútbol Profesional regulations.

[7] In 2019, Murcia won the Spanish Royal Federation Cup for the first time with a penalty shootout victory over CD Tudelano.

[8] Note: Flags indicate national team as defined under FIFA eligibility rules; some limited exceptions apply.