[2] She is known for her portrayal of Lizzy on the Netflix series Russian Doll[3][4][5] and for her roles in independent films Appropriate Behavior, They Remain, and Mickey and the Bear.
[11] In October 2019, it was announced that Henderson would star alongside Sigourney Weaver and Kevin Kline in Amblin Partners' feature The Good House.
[12] In 2021, she joined the main cast of Freeform's Single Drunk Female as Olivia, a lesbian journalist.
[13] She joined cast of the Hulu comedy Sex Appeal in April 2021.
[18] Henderson received a Drama Desk Award for Outstanding Ensemble performance in Signature Theatre's 2015 revival of "The Wayside Motor Inn" by A.R.