[1][2] It was founded in 1866 as St. Mary's Hospital, a private, Catholic, general hospital, but was purchased in 1996 by the Sealy & Smith Foundation.

[3] The foundation renamed it and donated it to the university for use as a psychiatric, outpatient surgery, and research hospital.

[4][5][6][7] In 2008, severe flooding from Hurricane Ike damaged all UTMB facilities, including Rebecca Sealy Hospital.

The inpatient psychiatric unit closed and the building was renovated into offices and simulation labs.

This article relating to a hospital in Texas is a stub.