She studied English Literature and her husband was an economics student named Israel Moses Sieff.

[1] During the First World War, Sieff was active in charitable organizations that collected donations for the Jewish population of Poland (Charity Fund for Polish Jewry).

Sieff was there with Vera Weizmann and Edith Eder and they were surprised by the poor living conditions and she decided that they needed a women's organisation and a college of domestic economy in Jerusalem.

Sieff had been brought up to expect men to take the lead but she believed that women could better support the family by improving their traditional roles.

They had three sons and a daughter: The death of their son Daniel, who intended to be a scientist, at age 17 led Sieff – and with the financial support of his business partners and relatives by marriage, the Marks and Sacher families – to endow the 1934 creation, by Chaim Weizmann, of the Daniel Sieff Research Institute in Rehovot in present-day Israel.