Wheatley grew up in Teddington, Middlesex, where she went to St Catherine's convent school, before gaining her BA in English literature from the University of Wales, Lampeter.
Wheatley is best known as Amy Howard, the receptionist in the BBC's Casualty drama, a role which she played for four years from September 1997 until March 2001.
She has sung in many of the cabaret venues in the West End of London, including The Café Royal, The Ritz and The Savoy.
She has also sung at the Grand Opera House in Belfast in televised performances for BBC Northern Ireland, and at the Royal Albert Hall for The TV Times 'Christmas Carols with the Stars' event.
On 4 December 2007, she was a guest on The Paul O'Grady Show where she talked about her 12.5 stone (175 lb) weight loss after following the Slimming World plan, to coincide with the release of her weight-loss DVD.