[2] Best known for her role as Evelyn Powell in the Lifetime comedy-drama series Devious Maids (2013–16), as of 2021 she is starring as Hetty Woodstone on the CBS sitcom Ghosts.

[3] In 2008, she won the Obie Award for Distinguished Performance by an Actress for her role as Nazi-era German filmmaker Leni Riefenstahl in Jordan Harrison's Amazons and Their Men.

[5][6][7] She also acted in several other Off-Broadway plays, including Don Juan Comes Back from the War, The Tooth of Crime, and Hot 'N Throbbing.

[11] In early 2012, Marc Cherry cast Wisocky in his comedy-drama television pilot Devious Maids as Evelyn Powell, the main antagonist of the show.

[19] On January 5, 2015, Wisocky became engaged to Lap Chi Chu, a theatrical lighting designer, on the Pont de la Tournelle in Paris.