Berenson played junior ice hockey with the Regina Pats, participating in two Memorial Cups in 1956 and 1958.

Seven weeks into the 1967/1968 NHL season, the St. Louis Blues acquired Berenson and Barclay Plager from the New York Rangers.

[1] The six-goal total was one shy of the all-time NHL record (set by Joe Malone in 1920), and has been accomplished only once since.

Berenson was named team captain in 1970; however, as he was already 31 years old, the Blues felt his skills were in decline, and traded him in what was considered a shocking deal to the Detroit Red Wings, a multi-player trade receiving centre Garry Unger in return.

The trade rejuvenated him, and he was an effective player for three and a half seasons back in St. Louis before he retired after the 1977–1978 campaign.

On January 10, 2015, Berenson became the fourth coach in Division I men's hockey history to reach 800 career wins.

[4] On April 10, 2017, Berenson announced his retirement as head coach of the Michigan Wolverine men's ice hockey team after 33 years.