A functional coordination between these 2 mechanisms has been proposed to be the method of folate uptake in certain cell types.

Methotrexate (MTX) is an antifolate chemotherapeutic agent that is actively transported by the carrier-mediated uptake system.

[8] Other studies have also shown that individuals carrying the c.80AA polymorphism who are treated with methotrexate have higher levels of this anti-folate chemotherapeutic agent.

Personalized dosing of the drug depending on the patient's genotype may therefore be required.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.