Her work includes Yeh Rishta Kya Kehlata Hai, Na Bole Tum Na Maine Kuch Kaha, Chakravartin Ashoka Samrat, Tujhse Hai Raabta, Gul Makai, Fanaa: Ishq Mein Marjawan, Khatra Khatra Khatra, Tere Ishq Mein Ghayal and Laughter Chefs – Unlimited Entertainment.

[3][4] Shaikh started her career as a child actor at the age of 6 with Neer Bhare Tere Naina Devi.

[5][6][7] In 2012, she starred in Me Aajji Aur Sahib and Yeh Rishta Kya Kehlata Hai.

[16][17] In 2022, Reem Shaikh was seen as Paakhi Srivastava Raichand in Colors TV's Fanaa: Ishq Mein Marjawan opposite Zain Imam and Akshit Sukhija.

[18] In 2023, she was seen in Colors TV's series Tere Ishq Mein Ghayal playing dual roles, Eisha Sharma and Kavya.