Florentino Ameghino Refuge (64°25′S 58°57′W / 64.417°S 58.950°W / -64.417; -58.950) is an Antarctic refuge located on Cape Longing in the Trinity Peninsula, at the northern tip of the Antarctic Peninsula.

[2] It is at an altitude of 29 metres (95 ft) above sea level on Cape Longing, the southeastern tip of a peninsula that extends from the Nordenskjöld Coast on the east of the Antarctic Peninsula.

[1] The nearby Ameghino Gully is named for the Refugio Ameghino, which in turn is named after Florentino Ameghino (1854–1911), Argentine geologist and anthropologist; Director, Museum of Natural History, Buenos Aires, 1902–11.

[3] The Florentino Ameghino depot is the responsibility of the Argentine Army's Antarctic Department.

The National Antarctic Directorate reports that the refuge is inactive.