[2] Upon completing her fellowships, Mandryk joined the University of Saskatchewan's Human-Computer Interaction Lab under the guidance of Carl Gutwin to research video games.

[7] As an assistant professor, she co-received a Natural Sciences and Engineering Research Council grant to study how to increase university-aged students physical activity.

[8] In January 2015, Mandryk was selected as an inaugural member of the Royal Society of Canada’s College of New Scholars, Artists and Scientists.

[10] The following year, Mandryk and researchers at the Interaction Lab began developing concentration exercises to assist children with fetal alcohol spectrum disorder.

[12] During the COVID-19 pandemic in North America, Mandryk promoted the use of video games while isolating as a way to deal with stress, anxiety and other mental health challenges.